Cristian O’Flaherty, DVM, PhD

We are interested in the molecular mechanisms that drive the production of mature spermatozoa and their modulation by reactive oxygen species (ROS). The oxidative stress can damage spermatogenesis and sperm maturation, leading to increased defects in the sperm genetic information, motility machinery and the acquisition of fertilizing ability by the spermatozoon. On the other hand, when ROS are produced in low and physiological conditions, they trigger and modulate signalling events that allow the spermatozoon to have fertilizing competence. We are also interested in the relationships between the gut microbiome and male reproduction.

Areas of research:

1) The molecular mechanisms driven by lipid signalling to allow the production of ROS and regulate sperm capacitation.

2) Redox protein modifications in the antioxidant response in mammalian spermatozoa. ROS promote oxidative modifications (thiol oxidation, tyrosine

3) Impact of gut microbiota on the health and disease of the male reproductive system and how gut microbiota can be manipulated to improve male fertility.

Our research is funded by CIHR and the MI4-Pathy Family Foundation.

Elizabeth Pranov
BSc student (Honours program)
elizabeth.pranov@mail.mcgill.ca

Chika Onochie
MSc candidate
chika.onochie@mail.mcgill.ca

Steven Serafini
PhD candidate
steven.serafini@mail.mcgill.ca