Cancers of the Reproductive Systems

Cancers of the Reproductive Systems

Cancers of the reproductive systems represent a major public health concern, affecting both women and men. Research in this area aims to better understand the biological mechanisms underlying these diseases in order to improve prevention, early diagnosis, and therapeutic approaches. Within the RQR, several teams focus on the hormonal, inflammatory, and genetic factors involved in the development of these cancers. Interactions between the tumor microenvironment and cancer cell progression also constitute a key research area, with the goal of identifying new therapeutic targets.

In women, reproductive system cancers include ovarian, fallopian tube, endometrial, cervical, and breast cancers. Yojiro Yamanaka studies the mechanisms involved in the development of ovarian and fallopian tube cancers. Éric Asselin’s lab seeks to understand how tumor cells resist chemotherapy in endometrial and ovarian cancers. Derek Boerboom focuses on intercellular communication mechanisms and how disruptions in these signals can lead to cancers affecting the ovary, uterus, and mammary gland. Nicolas Gévry concentrates on hormonal regulation in reproductive systems, particularly in breast cancer. André Tremblay analyzes how specific genes are switched on or off in breast and ovarian cancer, studying the mechanisms controlling gene expression that contribute to cancer development. Isabelle Plante’s team investigates the impact of endocrine disruptors — chemical substances that can alter hormonal function — on the development of breast cancer.

In men, prostate cancer is among the most common forms of cancer. Étienne Audet-Walsh focuses on the role of hormones and metabolic alterations in the initiation and progression of this disease, aiming to identify new therapeutic targets. Clémence Belleannée studies the cellular signaling mechanisms involved in prostate cancer.

Carlos Reyes-Moreno’s team focuses on the role of cytokines — molecules involved in inflammation — in cancer development. Their research explores how these signals affect the metabolism of cancer cells and tumor-associated macrophages, as well as the potential of natural or synthetic anti-inflammatory compounds to slow tumor progression.